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The article by the Zwolle researchers has already been peer-reviewed and assessed for value by colleagues. Yes, many medications have toxicity related to their use, however in this case it was just a high loading dose to find the pharmacokinetics running. Yes, I am quite sure there could have been side-effects, but limited to around 2 days or similar. And please, stop emotionally smearing the trials, and stop using words like “poisons”. And if you wish to talk high toxicity, talk to many cancer patients, who've to put up with far, far worse, week in week out.